Hydrochloric Acid → HCID 70196763, 화합물

HRID 342422

반응식

HRID 342422 반응식
[CH3:1][C:2]1[O:6][C:5]2[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:18](Cl)(=[O:21])[CH2:19][CH3:20].Cl>ClCCl>[CH3:1][C:2]1[O:6][C:5]2[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[C:3]=1[C:18](=[O:21])[CH2:19][CH3:20]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 132018972-Methyl-7-nitrobenzofuran

생성물 1

HCID 70196763HCID 70196763, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 2-methyl-7-nitrobenzo[b]furan (177 mg) and aluminum chloride (200 mg) in dichloromethane (5 ml) was added dropwise propionyl chloride (0.18 ml). The mixture was stirred at ambient temperature for 3 hours and poured into a mixture of ice and 1N-hydrochloric acid. The separated oil was extracted with dichloromethane and the extract was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was crystallized from diethyl ether to give 2-methyl-7-nitro-3-propionylbenzo[b]furan (215 mg).

후처리

  1. extractionThe separated oil was extracted with dichloromethane
  2. washthe extract was washed with brine
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo
  5. customThe residue was crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-1b3f6cc5efa24c4bb6df4f996b507601
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858995

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