Hydrochloric Acid → HCID 86753552, 화합물

HRID 342423

반응식

HRID 342423 반응식
[CH3:1][C:2]1[O:6][C:5]2[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[CH3:18][O:19]C(Cl)Cl.Cl>ClCCl>[CH:18]([C:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[C:5]=2[O:6][C:2]=1[CH3:1])=[O:19]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 21004Methane, dichloromethoxy-HCID 6451240Aluminum(III) ChlorideHCID 132018972-Methyl-7-nitrobenzofuran

생성물 1

HCID 86753552HCID 86753552, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a mixture of 2-methyl-7-nitrobenzo[b]furan (1.77 g) and aluminum chloride (2.66 g) in dichloromethane (40 ml) was added dropwise a solution of dichloromethyl methyl ether (3.6 ml) in dichloromethane (10 ml). The mixture was stirred at ambient temperature for 30 minutes and the reaction mixture was poured into a mixture of ice and 1N-hydrochloric acid. The separated oil was extracted with dichloromethane and the extract was washed with brine, aqueous saturated sodium bicarbonate and brine. Then, the solution was dried over sodium sulfate and evaporated in vacuo. The obtained oil was crystallized from diethyl ether to give 3-formyl-2-methyl-7-nitrobenzo[b]furan (1.83 g).

후처리

  1. extractionThe separated oil was extracted with dichloromethane
  2. washthe extract was washed with brine, aqueous saturated sodium bicarbonate and brine
  3. dry with materialThen, the solution was dried over sodium sulfate
  4. customevaporated in vacuo
  5. customThe obtained oil was crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-02a255bdb6784c9caf126c55bafac015
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858995

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