Triethylamine → 3-(Indan-5-yl)-1-isopropyl-2-thioxo-imidazolidin-4-one

HRID 343612

반응식

HRID 343612 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([N:10]=[C:11]=[S:12])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH:13]([NH:16][CH2:17][C:18](O)=[O:19])([CH3:15])[CH3:14].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([N:10]3[C:18](=[O:19])[CH2:17][N:16]([CH:13]([CH3:15])[CH3:14])[C:11]3=[S:12])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 414244NoName_76HCID 27593575-isothiocyanato-2,3-dihydro-1H-indene

생성물 1

HCID 153894913-(Indan-5-yl)-1-isopropyl-2-thioxo-imidazolidin-4-one수율 36.1%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The title compound was prepared by the procedure described in Example 18 using 17.5 g of indan-5-yl-isothiocyanate, 21.2 g of N-isopropyl glycine, 21.0 g of triethyl amine, and 300 mL of chloroform. Crystallization from ethanol afforded the title compound (9.9 g) as a white solid, m.p. 178°-180° C. Anal. Calcd. for. C15H18N2OS: C, 56.66; H, 6.61; N, 10.21. Found: C, 56.70; H, 6.67; N, 10.22. Mass spectrum (EI, M.+) m/z 274.

후처리

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from ethanol

출처 및 근거

ORD 기록
ord-bbdf46dbe9fe4895bc580feea3cdef89
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861517

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