Ethanol → 3-(4-Phenylphenoxy)-1-propanol

HRID 343636노트

반응식

HRID 343636 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C(O)C.Br[CH2:18][CH2:19][CH2:20][OH:21].[OH-].[Na+]>O>[OH:21][CH2:20][CH2:19][CH2:18][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 71034-HydroxybiphenylHCID 123083-Bromo-1-propanolHCID 14798Sodium Hydroxide2회

생성물 1

HCID 283517393-(4-Phenylphenoxy)-1-propanol수율 43%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into a 200 ml flask, 7.82 g (41.1 mmol) of 4-hydroxybiphenyl, 83 ml of ethanol, 6 g (43.2 mmol) of 3-bromo-1-propanol and a NaOH aqueous solution (1.73 g (43.2 mmol) of NaOH/6 ml of water) were sequentially added, and the mixture was heated and refluxed for 6.5 hours. To the reaction solution, 50 ml of water was added, whereupon precipitated crystals were collected by filtration and recrystallized from ethanol to obtain 4.0 g (yield: 43%) of 4-(3-hydroxypropoxy)biphenyl (1) as a colorless powder.

후처리

  1. temperaturethe mixture was heated
  2. temperaturerefluxed for 6.5 hours
  3. customwhereupon precipitated crystals
  4. filtrationwere collected by filtration
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-9e0ab87c47fd417cb1c3eb6c78e3154c
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861534

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