Hydrochloric Acid → HCID 54321377, 화합물

HRID 343796노트

반응식

HRID 343796 반응식
[OH-].[Na+].[Cl:3][C:4]1[C:5]([N:19](S(C)(=O)=O)[S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2.Cl>>[Cl:3][C:4]1[C:5]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54103043HCID 54103043, 화합물

생성물 1

HCID 54321377HCID 54321377, 화합물수율 84%

실험 절차

Aqueous sodium hydroxide (1M, 145 ml, 145 mmol) was added to a suspension of 6,7-dichloro-5-di(methanesulphonyl)amino-2,3-dimethoxy-quinoxaline (12.28 g, 28.6 mmol) and the mixture was stirred at room temperature for 16 hours. The resulting orange solution was treated with 2M hydrochloric acid (to pH 3) and the solid which precipitated was filtered off, washed with water and ether, and dried under reduced pressure at 80° C. to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)methanesulphonamide (8.46 g, 84%) as a white solid, mp 225°-227° C.

후처리

  1. customthe solid which precipitated
  2. filtrationwas filtered off
  3. washwashed with water and ether
  4. customdried under reduced pressure at 80° C.

출처 및 근거

ORD 기록
ord-0bde8bca09f74ff387dcb8abd6109cee
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05863917

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