Benzyl Chloride → Methyl(4-benzylthiophenyl)acetate

HRID 34410

반응식

HRID 34410 반응식
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([SH:11])=[CH:7][CH:6]=1.[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+].[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:7][CH:6]=1

참가 물질

6

반응물 4

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 14033178Methyl 2-(4-mercaptophenyl)acetate

생성물 1

HCID 54174016Methyl(4-benzylthiophenyl)acetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methyl(4-mercaptophenyl)acetate (0.2 mol) is heated at reflux with benzyl chloride (25 g, 0.2 mol) and K2CO3 (25 g, 0.2 mol) in 100 mL ethanol. The product is added to aqueous NaOH, extracted with ether, and purified by silica gel chromatography to yield methyl(4-benzylthiophenyl)acetate (3). (Scheme III, Step 1.)

후처리

  1. extractionextracted with ether
  2. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-3bd374c3ce354367ba30e6cb8a4808a1
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761420

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