Water → Benzene, [(5-chloropentyl)oxy]-

HRID 344238노트

반응식

HRID 344238 반응식
[H-].[Na+].[C:3]1([OH:9])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][Cl:16].O>CN(C)C=O>[O:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][Cl:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 996PhenolHCID 24758Sodium hydrideHCID 960701-Bromo-5-chloropentane

생성물 1

HCID 10655595Benzene, [(5-chloropentyl)oxy]-수율 93.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

60% Sodium hydride (1.4 g) was suspended in dimethylformamide (40 ml), and phenol (3 g) was added under ice-cooilng with stirring. The mixture was stirred at room temperature for 1 hr. The mixture was again ice-cooled, and 1-bromo-5-chloropentane (5.9 g) was added, which was followed by stirring at room temperature for 1.5 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried and the solvent was evaporated under reduced pressure to give 5.9 g of 5-phenoxypentyl chloride.

후처리

  1. stirringThe mixture was stirred at room temperature for 1 hr
  2. temperaturecooled
  3. stirringby stirring at room temperature for 1.5 hr
  4. extractionthe mixture was extracted with ethyl acetate
  5. washThe organic layer was washed with brine
  6. customdried
  7. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-88ef7066a5b54a70a194775a43b2a6e3
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

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