Water → 6-Phenoxyhexyl bromide

HRID 344243노트

반응식

HRID 344243 반응식
[H-].[Na+].[C:3]1([OH:9])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]Br.O>CN(C)C=O>[O:9]([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][Br:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 996PhenolHCID 123681,6-DibromohexaneHCID 24758Sodium hydride

생성물 1

HCID 1428786-Phenoxyhexyl bromide수율 100%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

60% Sodium hydride (1.16 g) was suspended in dimethylformamide (40 ml), and phenol (3 g) was added under ice-cooilng with stirring. The mixture was stirred at room temperature for 1 hr. The mixture was again ice-cooled, and a solution of 1,6-dibromohexane (7.78 g) in dimethylformamide (10 ml) was dropwise added, which was followed by stirring at room temperature for 2 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried and the solvent was evaporated under reduced pressure to give 8.2 g of 6-phenoxyhexyl bromide.

후처리

  1. stirringThe mixture was stirred at room temperature for 1 hr
  2. temperaturecooled
  3. stirringby stirring at room temperature for 2 hr
  4. extractionthe mixture was extracted with ethyl acetate
  5. washThe organic layer was washed with brine
  6. customdried
  7. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3dd84a54b3354a97be045c421743f8ac
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

반응 노트

불러오는 중…