Hydrochloric Acid → 6-Bromo-1-(2,4-difluorophenyl)-1-hexanone

HRID 344259

반응식

HRID 344259 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].Cl.[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=1>>[Br:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([C:19]1[CH:20]=[CH:21][C:16]([F:15])=[CH:17][C:18]=1[F:22])=[O:12]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 97411,3-DifluorobenzeneHCID 898486-Bromohexanoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 544758096-Bromo-1-(2,4-difluorophenyl)-1-hexanone

실험 절차

Aluminum chloride (1.31 g) was added to a solution of 6-bromohexanoyl chloride (2 g) in 1,3-difluorobenzene (20 ml) under ice-cooling and the mixture was stirred at room temperature for 2 hr. Ice water and conc. hydrochloric acid were added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give 1.16 g of 6-bromo-1-(2,4-difluorophenyl)-1-hexanone.

후처리

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water and brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure
  6. customThe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-b25b40d96be944df8711aacd4df2724f
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

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