Trimethyl orthoformate → HCID 11008070, 화합물

HRID 345209

반응식

HRID 345209 반응식
[OH:1][CH2:2][C:3](C)([CH3:6])[CH:4]=O.[CH:8]([O:13][CH3:14])([O:11][CH3:12])OC.Cl.O1CCOCC1.O(C)[Na]>CO>[CH3:14][O:13][CH:8]([O:11][CH3:12])[C:3]([CH3:6])([CH3:4])[CH2:2][OH:1]

참가 물질

6

반응물 4

HCID 9005Trimethyl orthoformateHCID 116993-Hydroxy-2,2-dimethylpropionaldehydeHCID 204431481,4-Dioxane hydrochlorideHCID 178418582HCID 178418582, 화합물

생성물 1

HCID 11008070HCID 11008070, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 24.4 g (0.24 mol) of 3-hydroxy-2,2-dimethylpropanal (Aldrich), 26 g (0.25 mol) of trimethyl orthoformate, and 0.5 mL of 6.8 N HCl/dioxane in 300 mL of methanol was allowed to stand at room temperature overnight. A slight excess of NaOCH3 was added and the solvent evaporated at reduced pressure. The residue was dissolved in ether and the mixture filtered. After evaporation of solvent and fractionation twice through a 15 cm Vigreux column, the product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%).

후처리

  1. customthe solvent evaporated at reduced pressure
  2. dissolutionThe residue was dissolved in ether
  3. filtrationthe mixture filtered
  4. customAfter evaporation of solvent and fractionation twice through a 15 cm Vigreux column
  5. customthe product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%)

출처 및 근거

ORD 기록
ord-2c753e33e993440b831c89dc3bb7c67a
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05055613

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