Acetic Anhydride → Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate

HRID 34525

반응식

HRID 34525 반응식
[CH2:1]([O:3][C:4](=[O:20])[CH2:5][C:6](=[O:19])[C:7]1[CH:12]=[C:11]([F:13])[C:10]([Cl:14])=[C:9]([N+:15]([O-:17])=[O:16])[C:8]=1[Cl:18])[CH3:2].[CH:21](OCC)(OCC)[O:22][CH2:23][CH3:24].C(OC(=O)C)(=O)C>>[Cl:18][C:8]1[C:9]([N+:15]([O-:17])=[O:16])=[C:10]([Cl:14])[C:11]([F:13])=[CH:12][C:7]=1[C:6]([C:5](=[CH:21][O:22][CH2:23][CH3:24])[C:4]([O:3][CH2:1][CH3:2])=[O:20])=[O:19]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 13733140Ethyl 2,4-dichloro-5-fluoro-3-nitro-beta-oxobenzenepropanoate

생성물 1

HCID 53944414Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate

실험 절차

244.8 g of ethyl(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acetate are heated with 166 g of triethyl orthoformate and 185 g of acetic anhydride at 150°-160° C. for 3 hours. The mixture is then concentrated in vacuo, and 270 g of ethyl benzoylethoxyacrylate are obtained as an oily residue.

후처리

  1. concentrationThe mixture is then concentrated in vacuo, and 270 g of ethyl benzoylethoxyacrylate
  2. customare obtained as an oily residue

출처 및 근거

ORD 기록
ord-96343b46141444b4b664ef971c0ef02e
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762831

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