Water → 2-Benzylcyclohexan-1-one

HRID 345309

반응식

HRID 345309 반응식
N1([CH:6]2[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)CCCC1.[CH2:12](Cl)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[OH2:20]>O1CCOCC1>[C:13]1([CH2:12][CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]2=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 7503Benzyl ChlorideHCID 139064Pyrrolidine, 1-cyclohexyl-

생성물 1

HCID 989452-Benzylcyclohexan-1-one

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 1-(1-pyrrolidinyl)cyclohexane (85.4 g) and benzyl chloride (100 ml) in dioxane (400 ml) was heated under reflux for 23 hours under nitrogen. Water (100 ml) was then added and the brown oil was distilled to give (2RS)-2-phenylmethylcyclohexanone (47.1 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 23 hours under nitrogen
  3. distillationthe brown oil was distilled

출처 및 근거

ORD 기록
ord-21da1710588a4bcabd47799acedec4b2
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05057513

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