Triethylamine → 5-Fluoro-1-methylcarbamoylisatin

HRID 34552

반응식

HRID 34552 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].C(N(CC)CC)C.[CH3:20][N:21]=[C:22]=[O:23]>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:22](=[O:23])[NH:21][CH3:20])[C:6](=[O:11])[C:5]2=[O:12]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 2365665-Fluoroisatin

생성물 1

HCID 142299485-Fluoro-1-methylcarbamoylisatin수율 74.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.

후처리

  1. temperaturecooling
  2. stirringThe mixture is stirred at room temperature for 30 minutes
  3. filtrationthe precipitates are taken by filtration

출처 및 근거

ORD 기록
ord-c25576f7a14c4b82ae9916dfb75fb8cd
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762839

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