Triethylamine → 5-Fluoro-1-methylcarbamoylisatin
반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].C(N(CC)CC)C.[CH3:20][N:21]=[C:22]=[O:23]>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:22](=[O:23])[NH:21][CH3:20])[C:6](=[O:11])[C:5]2=[O:12]참가 물질
5
실험 절차
A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.
후처리
- temperaturecooling
- stirringThe mixture is stirred at room temperature for 30 minutes
- filtrationthe precipitates are taken by filtration
출처 및 근거
- ORD 기록
- ord-c25576f7a14c4b82ae9916dfb75fb8cd
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04762839
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