Hydrochloric Acid → cis 4-Thiocyanatomethyl-3-amino-2-oxo-azetidine hydrochloride
반응식
[S:1]([CH2:4][C@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[N:10]1C(=O)C2=CC=CC=C2C1=O)[C:2]#[N:3].O.NN.[ClH:24]>O1CCOCC1>[ClH:24].[S:1]([CH2:4][C@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[NH2:10])[C:2]#[N:3]참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
A hot mixture of 1.45 g of the product of Step B in 15 ml of hot dioxane was cooled and 0.3 ml of hydrazine hydrate was added thereto. The mixture was stirred for 50 minutes at 20° C. and 7.5 ml of N hydrochloric acid were added thereto. The mixture was stirred for 15 hours and vacuum filtered. The filtrate was rinsed with water and the filtrate was evaporated to dryness to obtain 0.914 g of cis 4-thiocyanatomethyl-3-amino-2-oxo-azetidine hydrochloride.
후처리
- temperaturewas cooled
- stirringThe mixture was stirred for 15 hours
- filtrationvacuum filtered
- washThe filtrate was rinsed with water
- customthe filtrate was evaporated to dryness
출처 및 근거
- ORD 기록
- ord-22e4e9a0a5f4461485fc82d39aa8cd50
- 출처 데이터셋
- uspto-grants-1991_10
- 특허 번호
- US05057512
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