Methyl iodide → HCID 10752374, 화합물

HRID 345859노트

반응식

HRID 345859 반응식
[CH3:1][C:2]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][NH:3]1.[H-].[Na+].[CH3:20]I>CN(C)C=O>[CH3:1][C:2]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]1[CH3:20]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 130853136226-78-3

생성물 1

HCID 10752374HCID 10752374, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of (+)-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (1.0 g) in N,N-dimethylformamide (10 ml) was added sodium hydride (0.19 g) in ice-bath with stirring. After stirring for 30 minutes at room temperature, to the mixture was added methyl iodide (0.31 ml). And after stirring for an hour at room temperature, the mixture was poured into ice-water and extracted with ethyl acetate. The organic layer was washed with water, sodium chloride aqueous solution, dried over magnesium sulfate and evaporated in vacuo to give (+)-1,2-dimethyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (0.6 g).

후처리

  1. stirringAfter stirring for 30 minutes at room temperature, to the mixture
  2. stirringAnd after stirring for an hour at room temperature
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with water, sodium chloride aqueous solution
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-e71f606af1a64499bc7900b99c9c5d0b
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059608

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