Hydrochloric Acid → 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid

HRID 346176

반응식

HRID 346176 반응식
[F:1][C:2]([F:15])([F:14])[C:3]([NH:5][C@@H:6]1[C:12](=[O:13])[O:11][C:9](=[O:10])[CH2:8][CH2:7]1)=[O:4].[Al+3].[Cl-].[Cl-].[Cl-].Cl.C(O[CH2:25][CH3:26])(=O)C>C1C=CC=CC=1>[C:9]([CH2:8][CH2:7][C@H:6]([NH:5][C:3](=[O:4])[C:2]([F:15])([F:14])[F:1])[C:12]([OH:11])=[O:13])(=[O:10])[C:26]1[CH:25]=[CH:8][CH:7]=[CH:6][CH:12]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 2779007N-[(3S)-2,6-dioxooxan-3-yl]-2,2,2-trifluoroacetamideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 143908104-Benzoyl-2(S)-trifluoroacetamidobutyric acid

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Heat at reflux for 3 hours a mixture of N-trifluoroacetyl-L-glutamic anhydride (18.0 g, 80 mmol) and AlCl3 (23.5 g, 177 mmol) in dry benzene (400 ml). Allow to cool, treat with ice (400 ml), conc. HCl (100 ml), and ethyl acetate (EtOAc) (400 ml). Dry the organic layer and concentrate to obtain the title compound as a brown crystalline solid (25 g).

후처리

  1. temperatureHeat
  2. temperatureat reflux for 3 hours
  3. temperatureAllow to cool
  4. customDry the organic layer
  5. concentrationconcentrate

출처 및 근거

ORD 기록
ord-21cfeb1b6a624e999c1d039f19a069ff
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05061710

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