Isopropanol → N4-Phenylquinazoline-4,6-diamine

HRID 346412

반응식

HRID 346412 반응식
[C:1]1([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([N+:18]([O-])=O)[CH:16]=3)[N:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(C)C.O.NN>C(O)C.O.[Ni]>[C:1]1([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([NH2:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 3776IsopropanolHCID 24654Hydrazine hydrate (1:1)HCID 53281896-Nitro-N-phenylquinazolin-4-amine

생성물 1

HCID 5328187N4-Phenylquinazoline-4,6-diamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 19096565Water ethanol용매

실험 절차

A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customevaporated
  3. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-79f0fa1082b04b518e2114cf8bffea1e
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07172749B2

연결된 노트

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