Hydrazine hydrate (1:1) → 6-Amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline

HRID 346418노트

반응식

HRID 346418 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[C:20]3[C:15](=[CH:16][C:17]([O:24][CH2:25][CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)=[C:18]([N+:21]([O-])=O)[CH:19]=3)[N:14]=[CH:13][N:12]=2)[C:5]([F:9])=[CH:6][C:7]=1[Cl:8].O.NN>[Ni]>[NH2:21][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][C:17]=1[O:24][CH2:25][CH2:26][CH2:27][N:28]1[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1)[N:14]=[CH:13][N:12]=[C:11]2[NH:10][C:4]1[C:5]([F:9])=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 210800014-[(3,4-Dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

생성물 1

HCID 210800076-Amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline수율 75%

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline was reacted with hydrazine hydrate and Raney®Nickel, as described hereinabove, to produce 6-amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline in 75% yield.

출처 및 근거

ORD 기록
ord-52aec6f9f1334395bc181d147ce3e3db
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07172749B2

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