반응식
Cl.CN(C(ON1N=N[C:12]2[CH:13]=[CH:14][CH:15]=[N:16][C:11]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH:26](N(C(C)C)CC)(C)[CH3:27].[C:35](=[O:38])(O)[O-:36].[Na+]>CN(C=O)C>[CH2:15]1[CH2:14][CH2:13][CH:12]([C@H:11]([NH2:16])[C:35]([OH:36])=[O:38])[CH2:27][CH2:26]1참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
실험 절차
HCl (1.717 g, 6.87 mmol), HATU (2.618 g, 6.89 mmol) and diisopropylethyl amine (4.00 mL, 23.0 mmol) were added to a solution of the compound from Example 1, step 2 (1.704 g, 6.24 mmol) in anhydrous DMF (10 mL) at RT. The reaction was stirred at RT for 2.5 h. The reaction was diluted with saturated aqueous sodium bicarbonate (50 mL) and extracted with ether (150+100 mL). The organic phases were washed with water (100+50 mL), dried (MgSO4) and concentrated in vacuo to give 2.994 g of a yellow oil.
후처리
- extractionextracted with ether (150+100 mL)
- washThe organic phases were washed with water (100+50 mL)
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-0b852f742e434fdf8128ea80219336fe
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07173046B2
연결된 노트
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