Hydrochloric Acid → 1-(3,5-Difluoropyridin-2-yl)methanamine hydrochloride
반응식
[F:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:11]>[Pd].C(O)C.O1CCCC1>[ClH:11].[F:1][C:2]1[C:3]([CH2:9][NH2:10])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1참가 물질
5
실험 절차
A mixture of 3,5-difluoropicolinonitrile (1.4 g, 10 mmol), conc. HCl (12 ml) and 10% Pd—C (200 mg) in 1:1 ethanol/tetrahydrofuran was shaken under a hydrogen atmosphere (50 psi) for 5 h. The reaction mixture was filtered and the ethanol removed in vacuo. The remaining solution was lyophilized to afford an off-white solid (2.16 g, 100% yield). LCMS (M+H) calcd for C6H7F2N2: 145.06; found: 145.12.
후처리
- filtrationThe reaction mixture was filtered
- customthe ethanol removed in vacuo
출처 및 근거
- ORD 기록
- ord-413d93ee44f64b02b3b6a4237fc7b668
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07176196B2
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