Water → HCID 178435559, 화합물

HRID 348522노트

반응식

HRID 348522 반응식
C([C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C:7]3[CH2:12][CH2:13][CH2:14][C:6]=3[C:5]=2[CH:4]=1)#N.[H-].[Na+].[CH2:17](I)[CH3:18].O.[CH3:21][N:22](C=O)C>>[C:21]([C:10]1[C:9]2[C:5](=[C:6]3[C:14]([CH2:17][CH3:18])=[CH:13][CH:12]=[C:7]3[N:8]=2)[CH:4]=[CH:3][CH:11]=1)#[N:22]

참가 물질

6

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 6340IodoethaneHCID 24758Sodium hydrideHCID 210875601,2,3,4-Tetrahydrocyclopenta[b]indole-7-carbonitrile

생성물 1

HCID 178435559HCID 178435559, 화합물

실험 절차

A solution of 7-cyano-1,2,3,4-tetrahydrocyclopent[b]indole (0.224 g, 1.23 mmol) in anhydrous DMF (15 mL) was cooled to 0° C. and sodium hydride (60% dispersion in mineral oil, 74 mg, 3.07 mmol) was added. The reaction was stirred for 45 minutes then ethyl iodide (0.171 g, 1.47 mmol) was added and the reaction was allowed to warm to room temperature. The mixture was stirred for 15 hours then water was added. The product precipitated and was collected by filtration, washing with little water, brine and dichloromethane to give 0.287 g of title compound.

후처리

  1. stirringThe mixture was stirred for 15 hours
  2. customThe product precipitated
  3. filtrationwas collected by filtration
  4. washwashing with little water, brine and dichloromethane

출처 및 근거

ORD 기록
ord-153c6c89d1a442f7a4a8868c50c62615
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176322B2

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