Trimethyl orthoformate → Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

HRID 348524

반응식

HRID 348524 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6].[CH:14](OC)(OC)OC>>[CH3:13][N:12]1[C:11]2[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=2[N:1]=[CH:14]1

참가 물질

3

반응물 2

HCID 9005Trimethyl orthoformateHCID 15586064Methyl 3-amino-4-(methylamino)benzoate

생성물 1

HCID 965319Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

실험 절차

A solution of methyl 3-amino-4-methylaminobenzoate (prepared as in DE 1990390463 A1) (2.57 g, 14 mmol) in trimethyl orthoformate (50 mL) was refluxed for 16 hours. The solvent was then removed under reduced pressure to afford 2.31 g of product.

후처리

  1. customThe solvent was then removed under reduced pressure

출처 및 근거

ORD 기록
ord-32dc8e7f00a3425182a33ced2a8f8734
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176322B2

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