Sodium Hydroxide → (1-methyl-1H-benzo[d]imidazol-5-yl)methanol

HRID 348525

반응식

HRID 348525 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11](OC)=[O:12])=[CH:10][C:5]=2[N:4]=[CH:3]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C1COCC1>[OH:12][CH2:11][C:9]1[CH:8]=[CH:7][C:6]2[N:2]([CH3:1])[CH:3]=[N:4][C:5]=2[CH:10]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 965319Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 14518388(1-methyl-1H-benzo[d]imidazol-5-yl)methanol수율 58.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of methyl 1-methylbenzimidazole-5-carboxylate (1.6 g, 8.42 mmol) in dry THF (80 mL) was treated with LiAlH4 (1.59 g, 42.1 mmol) and the mixture stirred for 2 hours. 1.5 mL of 5% NaOH solution was then added, and the solid which precipitated was filtered through diatomaceous earth. The filtrate was collected and the solvent removed under reduced pressure to give 0.8 g of the title compound.

후처리

  1. customthe solid which precipitated
  2. filtrationwas filtered through diatomaceous earth
  3. customThe filtrate was collected
  4. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-ae711156e21b430f98d5dddcc4818b33
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176322B2

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