Sodium Hydroxide → (4-{[bis(1H-imidazol-2-ylmethyl)-amino]-methyl)-benzyl)-(4-dipropylaminomethylphenyl)-amine

HRID 348640노트

반응식

HRID 348640 반응식
[CH2:1]([N:4]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][NH:24][CH2:25][C:26]3[NH:27][CH:28]=[CH:29][N:30]=3)=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].[NH:31]1[CH:35]=[CH:34][N:33]=[C:32]1[CH:36]=O.C([BH3-])#N.[Na+].[OH-].[Na+]>CO.C(O)(=O)C>[NH:30]1[CH:29]=[CH:28][N:27]=[C:26]1[CH2:25][N:24]([CH2:23][C:20]1[CH:19]=[CH:18][C:17]([CH2:16][NH:15][C:12]2[CH:11]=[CH:10][C:9]([CH2:8][N:4]([CH2:5][CH2:6][CH3:7])[CH2:1][CH2:2][CH3:3])=[CH:14][CH:13]=2)=[CH:22][CH:21]=1)[CH2:36][C:32]1[NH:31][CH:35]=[CH:34][N:33]=1

참가 물질

7

반응물 4

HCID 14798Sodium HydroxideHCID 249551H-imidazole-2-carbaldehydeHCID 5003444Sodium cyanoborohydrideHCID 21084473(4-dipropylaminomethylphenyl)-(4-{[(1H-imidazol-2-ylmethyl)amino]methyl}benzyl)-amine

생성물 1

HCID 10028354(4-{[bis(1H-imidazol-2-ylmethyl)-amino]-methyl)-benzyl)-(4-dipropylaminomethylphenyl)-amine

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 887Methanol용매

실험 절차

The compound (199 mg) obtained in Example 43-1 was dissolved in methanol (6 ml) and then added with 2-imidazole carboxaldehyde (57.1 mg) and sodium cyanoborohydride (65.4 mg). The reaction solution was adjusted to pH 5 with the addition of acetic acid, followed by stirring at room temperature for 14 hours. The reaction solution was added with a 1 mol/l sodium hydroxide aqueous solution and then extracted with chloroform. Then, the organic layer was washed with saturated saline solution and dried with anhydrous sodium sulfate. After the solvent had been distilled off, the residue obtained was purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (231 mg) of the subject compound as a yellow solid.

후처리

  1. extractionextracted with chloroform
  2. washThen, the organic layer was washed with saturated saline solution
  3. dry with materialdried with anhydrous sodium sulfate
  4. distillationAfter the solvent had been distilled off
  5. customthe residue obtained
  6. customwas purified through silica gel column chromatography (chloroform/methanol)
  7. additiontreated with hydrochloric acid

출처 및 근거

ORD 기록
ord-8b57dd2be1da4e6191a757dbd9019e9b
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176227B2

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