1-(Hydroxymethyl)isoquinoline → Isoquinoline-1-carbaldehyde

HRID 348659

반응식

HRID 348659 반응식
[C:1]1([CH2:11][OH:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([CH:11]=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

참가 물질

4

반응물 1

HCID 27762471-(Hydroxymethyl)isoquinoline

생성물 1

HCID 265306Isoquinoline-1-carbaldehyde수율 85.1%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

Isoquinolin-1-yl-methanol (123.7 mg) was dissolved in chloroform (6.2 ml) and then added with manganese dioxide (chemically processed product) (1.24 g), followed by stirring at room temperature for 30 minutes. The reaction solution was filtrated through Celite and the solvent was then distilled off. The residue was dried under vacuum, thereby obtaining the subject compound (103.9 mg) as a brown solid.

후처리

  1. filtrationThe reaction solution was filtrated through Celite
  2. distillationthe solvent was then distilled off
  3. customThe residue was dried under vacuum

출처 및 근거

ORD 기록
ord-08bcf8622f984d33a60644c8f0c66571
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176227B2

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