1-(Hydroxymethyl)isoquinoline → Isoquinoline-1-carbaldehyde
반응식
[C:1]1([CH2:11][OH:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([CH:11]=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1참가 물질
4
실험 절차
Isoquinolin-1-yl-methanol (123.7 mg) was dissolved in chloroform (6.2 ml) and then added with manganese dioxide (chemically processed product) (1.24 g), followed by stirring at room temperature for 30 minutes. The reaction solution was filtrated through Celite and the solvent was then distilled off. The residue was dried under vacuum, thereby obtaining the subject compound (103.9 mg) as a brown solid.
후처리
- filtrationThe reaction solution was filtrated through Celite
- distillationthe solvent was then distilled off
- customThe residue was dried under vacuum
출처 및 근거
- ORD 기록
- ord-08bcf8622f984d33a60644c8f0c66571
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07176227B2
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