2,6-Dimethylaniline → N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide

HRID 34908

반응식

HRID 34908 반응식
[O:1]=[C:2]1[CH2:6][S:5][CH2:4][N:3]1[CH:7]([CH3:11])[C:8]([OH:10])=O.[CH3:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:14]=1[NH2:15].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[CH3:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:14]=1[NH:15][C:8](=[O:10])[CH:7]([N:3]1[C:2](=[O:1])[CH2:6][S:5][CH2:4]1)[CH3:11]

참가 물질

5

반응물 3

HCID 68962,6-DimethylanilineHCID 10868DicyclohexylcarbodiimideHCID 232453502-(4-Oxo-3-thiazolidinyl)propionic acid

생성물 1

HCID 13853984N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide수율 45.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.

후처리

  1. temperaturewas refluxed for 48 hours
  2. customThe resultant precipitate was removed by filtration
  3. customthe filtrate was evaporated in vacuo
  4. customThe residue was triturated with diethyl ether
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-6a9aab5ee7f74d7c9c9deececbc2446a
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764514

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