Hydrochloric Acid → 5-Nitro-2-(1-pyrrolidinyl)benzenamine

HRID 349734노트

반응식

HRID 349734 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:8]([NH:10]C(=O)C)[CH:9]=1)([O-:3])=[O:2].Cl.[OH-].[Na+]>C(OCC)(=O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:8]([CH:9]=1)[NH2:10])([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 609964HCID 609964, 화합물

생성물 1

HCID 129083915-Nitro-2-(1-pyrrolidinyl)benzenamine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

0.58 g (2.3 mmol) of N-(5-nitro-2-pyrrolidin-1-ylphenyl)acetamide was admixed with 12 ml of conc. hydrochloric acid and heated to reflux for 1.5 hours. The solution was added to 100 ml of ice/water, neutralized with 2 N sodium hydroxide solution and admixed three times with ethyl acetate. After the mixture had been dried, the solvent was distilled off under reduced pressure to obtain the product quantitatively as a red solid which was used for the reactions a-d described in Example 1 without further purification (reaction with the acyl isocyanate, reduction with SnCl2 and acylation with Ac2O).

후처리

  1. temperatureheated
  2. temperatureto reflux for 1.5 hours
  3. customAfter the mixture had been dried
  4. distillationthe solvent was distilled off under reduced pressure
  5. customto obtain the product quantitatively as a red solid which
  6. customdescribed in Example 1 without further purification (
  7. customreaction with the acyl isocyanate, reduction with SnCl2 and acylation with Ac2O)

출처 및 근거

ORD 기록
ord-c211579ec17544f3acd4387814493215
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179941B2

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