Acetic Acid → 5-Methanesulfonyl-1H-indole-2-carboxylic acid

HRID 349763

반응식

HRID 349763 반응식
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=2)=[O:4].[Li+].[OH-].C(O)(=O)C>C1COCC1.O>[CH3:17][S:14]([C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[NH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:13]2)(=[O:16])=[O:15]

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 3939Lithium HydroxideHCID 735868Methyl 5-(methylsulfonyl)-1H-indole-2-carboxylate

생성물 1

HCID 223944465-Methanesulfonyl-1H-indole-2-carboxylic acid수율 23.8%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the 5-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester (0.49 g) in THF (12 mL) and water (4 ml) was added LiOH (0.098 g). The reaction mixture was left to stir for 2 hours. Acetic acid was added and the product extracted with dichloromethane. The organic extracts were combined, dried with magnesium sulfate, filtered and the filtrate evaporated to give the title compound as a solid (0.110 g).

후처리

  1. waitThe reaction mixture was left
  2. extractionthe product extracted with dichloromethane
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-59bd6241b13b4cf58ff933b7a25a70c8
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179922B2

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