Ammonia → HCID 178436224, 화합물

HRID 35029노트

반응식

HRID 35029 반응식
[Na].C([S:9][C:10]1[N:11]([C:18]2[C:23]([CH2:24][CH3:25])=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:26][CH3:27])[C:12]([C:15]([OH:17])=[O:16])=[CH:13][N:14]=1)C1C=CC=CC=1.N.[Cl-].[NH4+].Cl>O>[CH2:26]([C:19]1[CH:20]=[CH:21][CH:22]=[C:23]([CH2:24][CH3:25])[C:18]=1[N:11]1[C:12]([C:15]([OH:17])=[O:16])=[CH:13][N:14]=[C:10]1[SH:9])[CH3:27]

참가 물질

7

반응물 5

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 13799565HCID 13799565, 화합물

생성물 1

HCID 178436224HCID 178436224, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2.3 g (0.1 mol) of sodium were added in portions to a suspension of 5 g (0.014 mol) of 2-benzylthio-1-(2,6-diethylphenyl)-imidazole-5-carboxylic acid in 50 ml of liquid ammonia at -40° to -50° C. After 1 hour, 6 g of ammonium chloride were added at the same temperature, and the mixture was allowed to warm up to room temperature overnight. The residue was taken up in 200 ml of water, and the solution was acidified to pH 3 with semiconcentrated hydrochloric acid and filtered under suction. 3.0 g (79% of theory) of 1-(2,6-diethylphenyl)-2-mercaptoimidazole-5-carboxylic acid, a solid having a melting point above 230° C., were obtained.

후처리

  1. filtrationfiltered under suction
  2. customwere obtained

출처 및 근거

ORD 기록
ord-b8679006a4264c0387f20959b5088f79
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764624

반응 노트

불러오는 중…