홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4-Methylmorpholine → (r)-2-[n-(4-Chlorophenyl)carbamoyloxy]-n-[4-(2-methoxyiminopiperidin-1-yl)phenyl]-2-phenylacetamide

HRID 350674
노트
인쇄 미리보기

반응식

HRID 350674 반응식
CN1CCOCC1.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([O:18][C@H:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20]([OH:22])=O)=[O:17])=[CH:11][CH:10]=1.[CH3:29][O:30][N:31]=[C:32]1[CH2:37][CH2:36][CH2:35][CH2:34][N:33]1[C:38]1[CH:43]=[CH:42][C:41]([NH2:44])=[CH:40][CH:39]=1.Cl.CN(C)CCCN=C=NCC.O.OC1C2N=NNC=2C=CC=1.C(=O)([O-])O.[Na+]>CN(C=O)C>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:16]([O:18][C@H:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20]([NH:44][C:41]2[CH:42]=[CH:43][C:38]([N:33]3[CH2:34][CH2:35][CH2:36][CH2:37][C:32]3=[N:31][O:30][CH3:29])=[CH:39][CH:40]=2)=[O:22])=[O:17])=[CH:13][CH:14]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 6

HCID 79724-MethylmorpholineHCID 516892Sodium BicarbonateHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 12992874(R)-(4-chlorophenylcarbamoyloxy)phenylacetic acidHCID 854347211-(4-aminophenyl)-piperidin-2-one O-methyl oximeHCID 178526939HCID 178526939, 화합물

생성물 1

HCID 91483835(r)-2-[n-(4-Chlorophenyl)carbamoyloxy]-n-[4-(2-methoxyiminopiperidin-1-yl)phenyl]-2-phenylacetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.2 101 mg (1.00 mmol) of 4-methylmorpholine are added to a solution of 183 mg (0.600 mmol) of (R)-(4-chlorophenylcarbamoyloxy)phenylacetic acid, 129 mg (0.588 mmol) of 1-(4-aminophenyl)piperidin-2-one O-methyl oxime, 192 mg (1.00 mmol) of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (DAPECI) and 91.9 mg (0.600 mmol) of hydroxybenzotriazole hydrate (HOBt) in 1 ml of DMF, and the mixture is stirred at room temperature for 24 hours. The reaction mixture is introduced into saturated sodium hydrogencarbonate solution, and the resultant precipitate is filtered off. The precipitate is chromatographed on a silica-gel column with petroleum ether/ethyl acetate as eluent, giving (R)-2-[N-(4-chlorophenyl)carbamoyloxy]-N-[4-(2-methoxyiminopiperidin-1-yl)phenyl]-2-phenylacetamide (“AA”) as a colourless solid; ESI 507.

후처리

  1. filtrationthe resultant precipitate is filtered off
  2. customThe precipitate is chromatographed on a silica-gel column with petroleum ether/ethyl acetate as eluent

출처 및 근거

ORD 기록
ord-4131f17bca1b4857b1fe69bb65f23642
출처 데이터셋
uspto-grants-2007_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07183277B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트