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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Pyridine → 2-(2-Methoxyphenyl)acetamide

HRID 350835
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HRID 350835 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=O.[N:13]1C=CC=CC=1.C(OC(OC(C)(C)C)=O)(OC(C)(C)C)=O.C(=O)([O-])O.[NH4+]>C(#N)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([NH2:13])=[O:12]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 1049PyridineHCID 71342-Methoxyphenylacetic acidHCID 14013Ammonium BicarbonateHCID 90495Di-tert-butyl dicarbonate

생성물 1

HCID 806622-(2-Methoxyphenyl)acetamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-Methoxyphenylacetic acid (10.0 g, 60.1 mmol) was dissolved in acetonitrile (15 mL). Subsequently, pyridine (2.84 g, 36.1 mmol) and di-tert-butyl dicarbonate [Boc2O (19.6 g, 90.2 mmol)] were added thereto. The mixture was stirred for 10 minutes at room temperature, and then ammonium hydrogencarbonate (7.1 g, 90.2 mmol) were added. After completion of reaction, the reaction mixture was concentrated under reduced pressure. Thereafter, the resultant concentrate was added to water, and the resultant mixture was extracted with chloroform, followed by washing sequentially with 1M hydrochloric acid and brine. The resultant mixture was subjected to drying over magnesium sulfate and concentration under reduced pressure. The resultant concentrate was used in Production Example 18 without purification.

후처리

  1. customAfter completion of reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. concentrationThereafter, the resultant concentrate
  4. additionwas added to water
  5. extractionthe resultant mixture was extracted with chloroform
  6. washby washing sequentially with 1M hydrochloric acid and brine
  7. dry with materialto drying over magnesium sulfate and concentration under reduced pressure
  8. concentrationThe resultant concentrate
  9. customwas used in Production Example 18 without purification

출처 및 근거

ORD 기록
ord-19e63721000f4f039d20040447f1d817
출처 데이터셋
uspto-grants-2007_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07183295B2

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