Oxygen → 2-Hydroxy4,4-dimethyl-gamma-butyrolactone

HRID 351316

반응식

HRID 351316 반응식
C(OCC)(=O)C=C.ON1C(=O)C2=CC=CC=C2C1=O.O=O.[OH:22][CH:23]([CH2:29][C:30]([OH:33])([CH3:32])[CH3:31])[C:24]([O:26]CC)=O>C([O-])(=O)C.[Co+2].C([O-])(=O)C.C(#N)C.CC(O)C>[OH:22][CH:23]1[CH2:29][C:30]([CH3:31])([CH3:32])[O:33][C:24]1=[O:26]

참가 물질

8

반응물 4

HCID 977OxygenHCID 8821Ethyl AcrylateHCID 10665N-HydroxyphthalimideHCID 11378808Ethyl 2,4-dihydroxy-4-methylpentanoate

생성물 1

HCID 101977032-Hydroxy4,4-dimethyl-gamma-butyrolactone

시약·촉매·용매 3

HCID 6277Cobalt diacetate촉매HCID 3776Isopropanol용매HCID 6342Acetonitrile용매

실험 절차

A mixture of 3 mmol of ethyl acrylate, 3 ml of 2-propanol, 0.6 mmol of N-hydroxyphthalimide, 0.003 mmol of cobalt(II) acetate, 0.015 mmol of acetylacetonatocobalt(III), and 1 ml of acetonitrile was stirred at 60° C. in an oxygen atmosphere (1 atm) for 12 hours. A gas chromatographic analysis of products in a reaction mixture revealed that ethyl 2,4-dihydroxy-4-methylpentanoate and α-hydroxy-γ,γ-dimethyl-γ-butyrolactone were formed in yields of 1.5% and 75%, respectively, with a conversion from ethyl acrylate of 81%.

출처 및 근거

ORD 기록
ord-18d516d3031f4293a26a4586fe747ca1
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183423B1

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