Acetoacetic Acid → Atorvastatin lactone

HRID 351459

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:31][CH2:32][C:33](=O)[CH2:34][C:35](=[O:42])[CH2:36][C:37]([O:39]CC)=[O:38])[C:10]([CH:28]([CH3:30])[CH3:29])=[C:11]([C:19](=[O:27])[NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.C(O)(=O)CC(C)=O.C(OCC)(=O)CC(C)=O>>[C:21]1([NH:20][C:19]([C:11]2[C:12]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[N:9]([CH2:31][CH2:32][C@@H:33]3[CH2:34][C@@H:35]([OH:42])[CH2:36][C:37](=[O:39])[O:38]3)[C:10]=2[CH:28]([CH3:30])[CH3:29])=[O:27])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

반응물 3

HCID 96Acetoacetic Acid

HCID 8868Ethyl Acetoacetate

HCID 113307057-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dioxo-heptanoic acid, ethyl ester

생성물 1

HCID 6483036Atorvastatin lactone

실험 절차

In a process analogous to Step 5 METHOD A, by substituting the appropriate ester or amide of acetoacetic acid for ethyl acetoacetate, one obtains the following compounds:

후처리

customobtains the following compounds

출처 및 근거

ORD 기록: ord-366f902b373f4b91ab431912b2e6de22
출처 데이터셋: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07183408B2

연결된 노트

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