Acetamidomalonic acid diethyl ester → Diethyl 2-acetamido-2-(diphenylmethyl)malonate

HRID 35154

반응식

HRID 35154 반응식
[Na].[C:2]([NH:5][CH:6]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:4])[CH3:3].[C:17]1([CH:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)Br)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(O)C>[C:2]([NH:5][C:6]([CH:23]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:4])[CH3:3]

참가 물질

5

반응물 3

HCID 14041Acetamidomalonic acid diethyl esterHCID 236603BromodiphenylmethaneHCID 5360545Sodium

생성물 1

HCID 14211495Diethyl 2-acetamido-2-(diphenylmethyl)malonate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dissolve sodium (2 g) in 400 ml ethanol and add diethyl acetamidomalonate (10.4 g). Stir 5 minutes, add diphenyl bromomethane (12.4 g), and stir 7 hours at room temperature. Acidify the reaction mixture, partition between water and methylene chloride (CH2Cl2), dry the organic layer over magnesium sulfate (MgSO4), filter, and evaporate the solvent to obtain the crude title compound as a pale yellow oil. Rf (silica gel; Et2O)=0.89.

후처리

  1. stirringstir 7 hours at room temperature
  2. custompartition between water and methylene chloride (CH2Cl2)
  3. dry with materialdry the organic layer over magnesium sulfate (MgSO4)
  4. filtrationfilter
  5. customevaporate the solvent

출처 및 근거

ORD 기록
ord-18b2b873df424d9bacf447d4ae203cba
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766109

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