Acetone → (2R)-3,4-Dihydro-2H-1-benzopyran-2-methanol

HRID 352422노트

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HRID 352422 반응식
[C:1]1([CH3:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:8]([OH:10])[CH3:9].[BH4-].[Na+].Cl.C[C:15](=[O:17])C>O>[O:10]1[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH2:7][CH2:9][C@@H:8]1[CH2:15][OH:17]

참가 물질

7

반응물 5

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 702EthanolHCID 1140TolueneHCID 4311764Sodium borohydride

생성물 1

HCID 7170029(2R)-3,4-Dihydro-2H-1-benzopyran-2-methanol

시약·촉매·용매 1

HCID 962Water용매

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온도
50 °C

실험 절차

A mixture of toluene (1000 ml) and ethanol (absolute. 520 ml) was stirred. Sodium borohydride (2.13 mol) was added at room temperature, under an inert atmosphere. The mixture was heated to 50° C. Intermediate (2) (2.14 mol) was added dropwise at 50° C. in a 90-minutes period (exothermic temperature rise of 15° C., cooling required). The reaction mixture was stirred for 90 minutes at 50° C. Water (1500 ml) was added while stirring. Then, 2-propanone (100 ml) was added dropwise under slight cooling. The mixture was decomposed with HCl (180 ml). The organic layer was separated, dried, filtered and the solvent evaporated, yielding 295 g of (−)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanol (interm. 3).

후처리

  1. temperature(exothermic temperature rise of 15° C., cooling required)
  2. stirringThe reaction mixture was stirred for 90 minutes at 50° C
  3. stirringwhile stirring
  4. customThe organic layer was separated
  5. customdried
  6. filtrationfiltered
  7. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-48d0bd0bab224dc489fc278754a6a219
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747045B2

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