Hydrochloric Acid → HCID 20508351, 화합물
반응식
[F:1][CH:2]([F:9])[CH:3]([CH2:5][C:6]([OH:8])=[O:7])[NH2:4].[C:10](Cl)(=[O:12])[CH3:11].Cl>[OH-].[Na+].O1CCOCC1>[F:1][CH:2]([F:9])[CH:3]([NH:4][C:10](=[O:12])[CH3:11])[CH2:5][C:6]([OH:8])=[O:7]참가 물질
6
실험 절차
To a solution of 2 mmole of beta-difluoromethyl beta-alanine in 5 ml of 1 N sodium hydroxide at 0° C. are added simultaneously from two syringes 160 mg of acetyl chloride diluted in 1 ml of dioxane and 2 ml of 1 N sodium hydroxide. After 30 minutes at 0° C. the solution is acidified by the addition of 6 N hydrochloric acid, then extracted well with dichloromethane. The organic phase is dried and concentrated to afford 3-difluoromethyl-3-(1-oxo-ethylamino) propionic acid.
후처리
- extractionextracted well with dichloromethane
- customThe organic phase is dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-14e0c993636b4027b54bdc5a80a8ffc5
- 출처 데이터셋
- uspto-grants-1983_03
- 특허 번호
- US04375477
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