N-(Cyanomethyl)-phthalimide → 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide

HRID 356104

반응식

HRID 356104 반응식
[C:1]1(=[O:14])[N:5]([CH2:6][C:7]#[N:8])[C:4](=[O:9])[C:3]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:2]12.P([S-])(OCC)(OCC)=[S:16]>Cl.C(OCC)(=O)C>[C:4]1(=[O:9])[N:5]([CH2:6][C:7]([NH2:8])=[S:16])[C:1](=[O:14])[C:2]2=[CH:13][CH:12]=[CH:11][CH:10]=[C:3]12

참가 물질

5

반응물 2

HCID 345881N-(Cyanomethyl)-phthalimideHCID 1385274Diethyl dithiophosphate, potassium salt

생성물 1

HCID 246961282-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8857Ethyl Acetate용매

실험 절차

In a 20 ml 4N solution of hydrogen chloride in ethyl acetate, 3.07 g of phthalimidoacetonitrile was dissolved. To the resulting solution, 3.17 ml of O,O-diethyl dithiophosphate was added, followed by stirring at room temperature for 6 hours. The precipitate formed was collected by filtration, and washed successively with ethyl acetate and diethyl ether, whereby 2.29 g of phthalimidothioacetamide was obtained.

후처리

  1. customThe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed successively with ethyl acetate and diethyl ether

출처 및 근거

ORD 기록
ord-447b185e459e4007afb89349afc2be54
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834499

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