Hydrochloric Acid → Methyl 3-oxo-4-phthalimidobutyrate

HRID 356207노트

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HRID 356207 반응식
C[C:2]1(C)[O:9][C:7](=[O:8])[CH2:6][C:4](=[O:5])O1.N1C=CC=CC=1.[C:17]1(=[O:31])[N:21]([CH2:22]C(Cl)=O)[C:20](=[O:26])[C:19]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:18]12.Cl>ClCCl>[O:5]=[C:4]([CH2:22][N:21]1[C:20](=[O:26])[C:19]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:18]2[C:17]1=[O:31])[CH2:6][C:7]([O:9][CH3:2])=[O:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-

생성물 1

HCID 2841582Methyl 3-oxo-4-phthalimidobutyrate수율 70.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of Meldrum's acid (14.4 g, 0.10 mol) and pyridine (15.8 g, 0.20 mol) in dichloromethane (100 mL) was added dropwise at 0° C., taking 10 minutes, a solution of phthalimidoacetyl chloride (24.6 g,. 0.11 mol) in dichloromethane (50 mL). The mixture was stirred for 30 minutes at the same temperature and for 30 minutes at room temperature. To the reaction mixture was added 1N HCl (200 mL), then insoluble material was filtered off. The aqueous layer was separated, and the organic layer was washed with water, dried over magnesium sulfate and subjected to filtration. The filtrate was concentrated under reduced pressure. The concentrate was suspended in methanol (200 mL), which was refluxed for 1.5 hour. The reaction mixture was left standing for cooling. Crystalline precipitate was collected by filtration and washed with methanol to give the object compound (18.4 g, 70%), m.p.139°-140° C.

후처리

  1. filtrationinsoluble material was filtered off
  2. customThe aqueous layer was separated
  3. washthe organic layer was washed with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationsubjected to filtration
  6. concentrationThe filtrate was concentrated under reduced pressure
  7. temperaturewhich was refluxed for 1.5 hour
  8. waitThe reaction mixture was left
  9. temperaturefor cooling
  10. filtrationCrystalline precipitate was collected by filtration
  11. washwashed with methanol

출처 및 근거

ORD 기록
ord-c1273e46885b469c80e2ca0eb5120f7e
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05834463

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