Formic Acid → 3beta-Formyloxy-androstene-17-one

HRID 356587

반응식

HRID 356587 반응식
[CH3:1][C@@:2]12[C:10](=[O:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH:13]=[C:14]3[CH2:19][C@@H:18]([OH:20])[CH2:17][CH2:16][C@:15]3([CH3:21])[C@H:5]1[CH2:4][CH2:3]2.O.[CH:23](O)=[O:24]>>[CH:23]([O:20][C@H:18]1[CH2:17][CH2:16][C@@:15]2([CH3:21])[CH:14]([CH2:13][CH2:12][C@@H:6]3[C@@H:5]2[CH2:4][CH2:3][C@@:2]2([CH3:1])[C@H:7]3[CH:8]=[CH:9][C:10]2=[O:11])[CH2:19]1)=[O:24]

참가 물질

4

반응물 3

HCID 284Formic AcidHCID 962WaterHCID 5881Dehydroepiandrosterone

생성물 1

HCID 1317209413beta-Formyloxy-androstene-17-one

반응 조건

온도
60 °C

실험 절차

Following the procedure described by Ringold (H. J. Ringold, et al., J. Am. Chem. Soc. 78, 816, 1956), dehydroepiandrosterone (2.88 g, 10 mmol) dissolved in 85% formic acid (100 mL) is heated at 60° C. for 1 h. After cooling, the mixture is poured into iced water and after 16 h, crystals are filtered and dried in vacuo.

후처리

  1. temperatureAfter cooling
  2. filtrationcrystals are filtered
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-c23a8e0841a64406bce4926a92eaf7b2
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05837700

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