Methyl iodide → Benzaldehyde, 2-methoxy-5-nitro-
반응식
[N+:1]([C:4]1[CH:11]=[C:8]([CH:9]=[O:10])[C:7]([OH:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].[H-].[Na+].[CH3:15]I>CN(C=O)C>[CH3:15][O:12][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:11][C:8]=1[CH:9]=[O:10]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of 5-nitrosalicylaldehyde (1.00 g, 6.0 mmol) in DMF (20 ml) was added NaH (246 mg) and methyl iodide (2.56 g, 18 mmol) at 0° C. The mixture was stirred for 8.5 hr at 60° C. After the reaction mixture was extracted with ether, the extract was washed with aqueous NaHCO3, brine and 5%-HCl/aq.NaCl, dried over MgSO4 and concentrated in vacuo to afford 2-methoxy-5-nitrobenzaldehyde (0.95 g, 87.8%) as a yellow needle.
후처리
- extractionAfter the reaction mixture was extracted with ether
- washthe extract was washed with aqueous NaHCO3, brine and 5%-HCl/aq
- dry with materialNaCl, dried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-8440ac320f3c4bc1ae9c1be85bec0d5e
- 출처 데이터셋
- uspto-grants-1998_11
- 특허 번호
- US05837711
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