Hydroxyamine hydrochloride → 1-Acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime

HRID 35709

반응식

HRID 35709 반응식
[C:1]([C:4]1([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH2:7][CH2:6][CH2:5]1)(=O)[CH3:2].Cl.[NH2:17][OH:18].O.O.O.C([O-])(=O)C.[Na+]>O>[C:1](=[N:17][OH:18])([C:4]1([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH2:7][CH2:6][CH2:5]1)[CH3:2]

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 130831391-Acetyl-1-(3,4-dichlorophenyl)cyclobutaneHCID 23665404Sodium Acetate Trihydrate

생성물 1

HCID 860311131-Acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane (4.86 g) prepared as described in Example 1, hydroxylamine hydrochloride (1.6 g), sodium acetate trihydrate (3.3 g), industrial methylated spirit (15 ml) and water (2 ml) was heated under reflux for twenty hours. The cooled reaction mixture was poured into water and the oil which separated was cooled to give a solid which was recrystallised from industrial methylated spirit to give 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime (m.p. 120°-121° C.).

후처리

  1. customprepared
  2. temperaturewas heated
  3. temperatureunder reflux for twenty hours
  4. customThe cooled reaction mixture
  5. customthe oil which separated
  6. temperaturewas cooled
  7. customto give a solid which
  8. customwas recrystallised from industrial methylated spirit

출처 및 근거

ORD 기록
ord-212ada1503ca49f38c304579d022218a
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04767790

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