Hydrochloric Acid → Ampicillin Trihydrate

HRID 357477

반응식

HRID 357477 반응식
[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].Cl>>[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].[OH2:9].[OH2:9].[OH2:9]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 6249Ampicillin

생성물 1

HCID 23565Ampicillin Trihydrate

실험 절차

The resultant crude protected ampicillin mixture is worked up by treating with a mixture of ice-water and concentrated HCl. After phase separation the aqueous phase is brought to pH 4.5. The title compound is obtained after filtration and washing with 90% aqueous acetone, followed by drying. Yield 66.34 g=89%. Purity 98.8%.

후처리

  1. customAfter phase separation the aqueous phase

출처 및 근거

ORD 기록
ord-1bf74494d5f2409fae1c1286e6520a37
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840885

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