Hydrochloric Acid → Acetyl hexamethyl tetralin, (S)-

HRID 35757

반응식

HRID 35757 반응식
[CH3:1][C:2]1([CH3:16])[C:11]2[C:6](=[CH:7][C:8]([CH3:12])=[CH:9][CH:10]=2)[C:5]([CH3:14])([CH3:13])[C@@H:4]([CH3:15])[CH2:3]1.[C:17](Cl)(=[O:19])[CH3:18].[Cl-].[Al+3].[Cl-].[Cl-].Cl>ClCCCl>[C:17]([C:9]1[CH:10]=[C:11]2[C:6]([C:5]([CH3:14])([CH3:13])[C@@H:4]([CH3:15])[CH2:3][C:2]2([CH3:16])[CH3:1])=[CH:7][C:8]=1[CH3:12])(=[O:19])[CH3:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 13175223(S)-1,1,3,4,4,6-hexamethyl1,2,3,4-tetrahydronaphthalene

생성물 1

HCID 1427578Acetyl hexamethyl tetralin, (S)-수율 90.1%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

To a solution of (S)-1,1,3,4,4,6-hexamethyl1,2,3,4-tetrahydronaphthalene ([α]546 -49.1° (C=1 in n-hexane)) (100.0 g; 0.463 mol) in 1,2-dichloroethane (300 g), acetyl chloride (38.0 g; 0.484 mol) and anhydrous aluminum chloride (71.0 g; 0.533 mol) were added, and the resultant mixture was stirred at 20° C. for 1 hour. The reaction mixture was treated with 10% hydrochloric acid (300 ml) and then separated into a water layer and an organic layer. The organic layer was washed with dilute hydrochloric acid and saturated sodium carbonate solution, dried and concentrated to give (S)-7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (107.5 g; 0.417 mol; 90%). B.P., 109° C./0.2 mmHg. [α]546 -36.9° (C=1 in ethanol).

후처리

  1. customseparated into a water layer
  2. washThe organic layer was washed with dilute hydrochloric acid and saturated sodium carbonate solution
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7ee0d5de55494c5eae7b8eaad9557cef
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04767882

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