Ethyl Acetoacetate → HCID 54710578, 화합물

HRID 357834노트

반응식

HRID 357834 반응식
[C:1](OCC)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[H-].[Na+].C([Li])CCC.[C:17]([C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCCCCC.C(O)(=O)C.O1CCCC1>[OH:4][C:3]1[CH2:5][C:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)([C:25]2[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=2)[O:24][C:1](=[O:6])[CH:2]=1

참가 물질

8

반응물 4

HCID 8868Ethyl AcetoacetateHCID 24758Sodium hydrideHCID 267314-BenzoylpyridineHCID 178418339Butyllithium

생성물 1

HCID 54710578HCID 54710578, 화합물

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 8028Tetrahydrofuran용매HCID 8058Hexane용매

실험 절차

The title compound was prepared as described in General Method 1 using 90 mmol of ethyl acetoacetate, 99 mmol of NaH 60% dispersion in oil, 95 mmol of 1.6M n-butyl lithium in hexane and 90 mmol of 4-benzoylpyridine and 250 mL of tetrahydrofuran. The reaction mixture was acidified with acetic acid and the crude solid was washed with ice water (m.p. 148°-150° C).

후처리

  1. washthe crude solid was washed with ice water (m.p. 148°-150° C)

출처 및 근거

ORD 기록
ord-8d8abd42ff4b40b8be27ffad3d770348
출처 데이터셋
uspto-grants-1998_11
특허 번호
US05840751

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