Sulfuric Acid → HCID 178484896, 화합물

HRID 358261노트

반응식

HRID 358261 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[CH2:13](OC(OCC)OCC)C.OS(O)(=O)=O.[CH3:28][NH2:29]>C(O)C.Cl>[CH3:28][NH:29][CH:13]=[N:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 1118Sulfuric AcidHCID 6329MethylamineHCID 31214Ethyl orthoformateHCID 178507418HCID 178507418, 화합물

생성물 1

HCID 178484896HCID 178484896, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

A mixture of 1.59 gm of 4-(4-aminophenyl)-1-H-imidazole and 2.22 gm of triethylorthoformate was heated for 30 minutes at 100° C. in the presence of a catalytic amount of 96% H2SO4. A 33% solution of methylamine in ethanol (9.5 gm) was then added dropwise to the cooled reaction mixture. The solution was stirred at room temperature for twenty hours and then evaporated to dryness. The residue obtained was dissolved in 10% hydrochloric acid, and the acid solution was washed with ethyl acetate and then adjusted to pH 10 with 10% NaOH. The product which separated was extracted with ethyl acetate to yield, after evaporation of the solvent, 0.45 gm of the desired compound.

후처리

  1. customevaporated to dryness
  2. customThe residue obtained
  3. washthe acid solution was washed with ethyl acetate
  4. customThe product which separated
  5. extractionwas extracted with ethyl acetate
  6. customto yield
  7. customafter evaporation of the solvent, 0.45 gm of the desired compound

출처 및 근거

ORD 기록
ord-324a21efb5cb4e4c8be2b7e4d666cfff
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04465841

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