3,4-dihydro-2H-pyran → 2-(5-Bromopentyloxy)tetrahydro-2H-pyran

HRID 358629

반응식

HRID 358629 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7].[O:8]1[CH:13]=[CH:12][CH2:11][CH2:10][CH2:9]1>P(Cl)(Cl)(Cl)=O>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][O:8]1

참가 물질

4

반응물 2

HCID 80803,4-dihydro-2H-pyranHCID 1187091-Pentanol, 5-bromo-

생성물 1

HCID 27869332-(5-Bromopentyloxy)tetrahydro-2H-pyran수율 52%

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride촉매

실험 절차

Three drops of phosphoryl chloride were added to a stirred mixture of 5-bromopentanol (34.3 g, 205 mmol) and dihydropyran (19.0 g, 226 mmol). After standing for one hour, the mixture was fractionated. Yield 34.7 g, b.p. 102° C. (0.2 bar). Chromatography on alumina eluted with petroleum ether gave the pure title compound (25.1 g, 52% of theory) as an oil.

후처리

  1. washChromatography on alumina eluted with petroleum ether

출처 및 근거

ORD 기록
ord-fd69aa4689b64c6c9ad67cbdf7ab837b
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997847

연결된 노트

불러오는 중…