Hydrochloric Acid → HCID 15812073, 화합물

HRID 359278노트

반응식

HRID 359278 반응식
O1CCCC1.[CH3:6][C:7]([NH:10][C:11]1[O:12][C:13]([C:20]([O:22]CC)=[O:21])=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=1)([CH3:9])[CH3:8].[OH-].[Na+].Cl>O>[CH3:9][C:7]([NH:10][C:11]1[O:12][C:13]([C:20]([OH:22])=[O:21])=[C:14]([C:16]([F:17])([F:19])[F:18])[N:15]=1)([CH3:6])[CH3:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 20064741Ethyl 2-[(1,1-dimethylethyl)amino]-4-trifluoromethyl-5-oxazolecarboxylate

생성물 1

HCID 15812073HCID 15812073, 화합물수율 9.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A reaction vessel was charged with 200 ml tetrahydrofuran and 28 g (100 mmol) of ethyl 2-[(1,1dimethylethyl)amino]-4-trifluoromethyl-5-oxazolecarboxylate (prepared by Example 6). With this mixture stirred at ambient temperature, 50% aqueous sodium hydroxide (16 g; 200 mmol) was added followed by 50 ml water as a rinse. The reaction mixture was stirred at ambient temperature for 16 hours. The mixture was then poured into 500 ml of 5% hydrochloric acid. After cooling with an ice bath, the mixture was filtered, washed with water, and then dried to yield 2.4 g of a white powder which was recrystallized from ethyl acetate to a crystalline product (m.p.=256°-258° C.) identified in Table I.

후처리

  1. stirringThe reaction mixture was stirred at ambient temperature for 16 hours
  2. temperatureAfter cooling with an ice bath
  3. filtrationthe mixture was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-25e059f518784467abbaad415a2e5cf5
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05000775

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