Sodium hydride → 3-Cyano-2-(6-dimethylaminohexyloxy)pyridine

HRID 359478노트

반응식

HRID 359478 반응식
[CH3:1][N:2]([CH3:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][OH:9].[Na].[H-].[Na+].Cl[C:15]1[C:20]([C:21]#[N:22])=[CH:19][CH:18]=[CH:17][N:16]=1>C1(C)C=CC=CC=1>[C:21]([C:20]1[C:15]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:10])[CH3:1])=[N:16][CH:17]=[CH:18][CH:19]=1)#[N:22]

참가 물질

6

반응물 4

HCID 24758Sodium hydrideHCID 746236-Dimethylaminohexan-1-olHCID 810792-ChloronicotinonitrileHCID 5360545Sodium2회

생성물 1

HCID 151356393-Cyano-2-(6-dimethylaminohexyloxy)pyridine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

6-Dimethylaminohexanol is converted into its sodium salt with sodium hydride in toluene, followed by reaction of the sodium salt with 2-chloro-3-cyanopyridine to give 3-cyano-2-(6-dimethylaminohexyloxy)pyridine.

출처 및 근거

ORD 기록
ord-92f31da8126842d3985a154613783827
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05001137

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