Cetyl Alcohol → 8-(Hexadecyloxy)-7-methoxy-1-octene

HRID 35957

반응식

HRID 35957 반응식
[H-].[Na+].[OH:3][CH2:4][CH:5]([O:12][CH3:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[CH2:11].S(C1C=CC(C)=CC=1)([O-])(=O)=O.[CH2:25](O)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>CN(C)C=O.O>[CH2:40]([O:3][CH2:4][CH:5]([O:12][CH3:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[CH2:11])[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH3:25]

참가 물질

7

반응물 4

HCID 2682Cetyl AlcoholHCID 24758Sodium hydrideHCID 85570p-ToluenesulfonateHCID 199395708-Hydroxy-7-methoxy-1-octene

생성물 1

HCID 199395658-(Hexadecyloxy)-7-methoxy-1-octene

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매2회

실험 절차

To a suspension of 7.4 g of 60% sodium hydride in 100 ml of dimethylformamide was added a solution of 8-hydroxy-7-methoxy-1-octene in 150 ml of dimethylformamide over 1.5 hours. A 63.4 g portion of the tosylate of 1-hexadecanol was added and the mixture was stirred for 18 hours, poured into water and extracted with ether. The ether solution was dried and evaporated. The residue was purified by chromatography giving 41.5 g of the title compound as a oil.

후처리

  1. extractionextracted with ether
  2. dry with materialThe ether solution was dried
  3. customevaporated
  4. customThe residue was purified by chromatography

출처 및 근거

ORD 기록
ord-95f61b892d9b4419a2ca820c0f9db754
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05411983

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