Hydrochloric Acid → 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate

HRID 35998

반응식

HRID 35998 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([N:16]2[CH2:21][CH2:20][N:19]([C:22]([CH:24]3[CH2:28][CH2:27][CH2:26][O:25]3)=[O:23])[CH2:18][CH2:17]2)[N:3]=1.[ClH:29]>CO>[ClH:29].[CH3:9][O-:12].[ClH:29].[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([N:16]2[CH2:21][CH2:20][N:19]([C:22]([CH:24]3[CH2:28][CH2:27][CH2:26][O:25]3)=[O:23])[CH2:18][CH2:17]2)[N:3]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 5401Terazosin

생성물 2

HCID 313Hydrochloric AcidHCID 867486641-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate수율 77.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of hydrogen chloride in methanol was prepared by bubbling the gas through dry methanol for several minutes. 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine (1.2 g, 3.1 mmol) was placed in an Erlenmeyer flask, together with a magnetic stirring bar, and the methanolic solution of hydrogen chloride was added until the solid had completely dissolved (about 13 mL). After the resulting mixture had stood at about 25° C. for several minutes, a precipitate formed. The mixture was cooled in an ice bath for thirty minutes and the precipitated solid collected by filtration to yield 1.1 g (2.41 mmol, 77.8%) of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate.

후처리

  1. customby bubbling the gas through dry methanol for several minutes
  2. dissolutionhad completely dissolved (about 13 mL)
  3. waitAfter the resulting mixture had stood at about 25° C. for several minutes
  4. customa precipitate formed
  5. temperatureThe mixture was cooled in an ice bath for thirty minutes
  6. filtrationthe precipitated solid collected by filtration

출처 및 근거

ORD 기록
ord-d3d3bb326fba4875ab2dbbc113d0b222
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05412095

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